Computational Insights on Sulfonamide Imprinted Polymers

Computational insights on sulfonamide imprinted polymers.

Molecular imprinting is one of the most efficient methods for preparing synthetic receptors that possess user defined recognition properties. Despite general success of non-covalent imprinting for a large variety of templates, some groups of compounds remain difficult to tackle due to their structural complexity. In this study we investigate preparation of molecularly imprinted polymers that ca...

Computational Design of Molecularly Imprinted Polymers

Artificial receptors have been in use for several decades as sensor elements, in affinity separation, and as models for investigation of molecular recognition . Although there have been numerous publications on the use of molecular modeling in characterization of their affinity and selectivity, very few attempts have been made on the application of molecular modeling in computational design of ...

Molecular Imprinted Polymers: A Review

Imprinted Polymers: Versatile New Tools in Synthesis

The use of molecularly imprinted polymers in synthetic organic chemistry is reviewed. These materials are prepared in the presence of a template for which they carry a functional and stereochemical “memory” and can be likened to artificial antibodies or enzymes. Their unique properties have been exploited by the use of imprinted polymers as stereoand regio-selective solid supports in condensati...

Influence of salt ions on binding to molecularly imprinted polymers.

Salt ions were found to have an influence on template binding to two model molecularly imprinted polymers (MIPs), targeted to penicillin G and propranolol, respectively, in water-acetonitrile mixtures. Water was detrimental to rebinding of penicillin G whereas propranolol bound in the entire water-acetonitrile range tested. In 100% aqueous solution, 3-M salt solutions augmented the binding of b...